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Diabetes Regeneration Therapy – A Novel Target Site Discovery

Diabetes Treatment Discovery
Credit: thesooperdiet.com

Science has no-doubt made life easier, yet diseases like diabetes are one of the leading causes of death. Scientists continue to carry out their research and discover new means to uncover novel treatment strategies for diabetes. 

With the advent of science and technology, scientists can find new techniques for preventing, curing, and mitigating disease. A hundred years ago, the discovery of insulin occurred that saved the lives of thousands and continues to do so up till the present. 

However, diabetic patients depend on insulin or other medicines for treating diabetes or controlling blood sugar levels. Moreover, throughout their lives. Scientists are now discovering novel techniques for methods that can remise diabetes or give a promising treatment. 

Diabetes In Old Times 

Diabetes is a disease of beta-cells of the pancreas leading to an unbalanced amount of glucose in the blood. Moreover, diabetic patients usually have high insulin resistance, due to which glucose absorption becomes slow and difficult. 

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Furthermore, diabetic patients have damaged beta-cells of the islet of Langerhans, resulting in insufficient insulin production. It also disturbs the homeostasis procedure for glucose balance, yielding higher levels of glucose in the blood. 

Diabetic complications increase the rate of death in many communities. Previous studies have shown that intensive insulin therapy has the potential to improve blood sugar levels and diabetes remission. However, intensive insulin therapy has side effects that can lead to complications and may lead to coma. With intensive insulin therapy, the risk of gaining weight increases drastically. Moreover, it may cause excessive dropping of blood sugar levels resulting in hypoglycemia leading to coma and death.

Also, currently, no therapy can regenerate damaged beta-cells of the pancreas. The discovery of inceptor is beneficial for treating both types of diabetic patients; type-1 and type-2 diabetes. 

What New Discovery Does Science Make For Treating Dysfunction Beta Cells?

The latest study from Helmholtz Zentrum Muenchen, the Technical University of Munich, and the German Center for Diabetes Research discovered a novel drug-able insulin inhibitor receptor called Inceptor.

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The discovery of Inceptor is remarkable as communities celebrate 100 years of insulin and 50 years of insulin receptor discovery. Inceptor increases the sensitization of insulin signaling pathways in beta cells of the pancreas. As a result, the development of insulin resistance decreases, and the possibility of beta-cell regeneration increases leading to diabetes remission.

According to the researcher, Heiko Lickert, the studies focus on the development of regenerative  approaches that can enable regrowth or repair of beta-cells leading to the synthesis of sufficient insulin. The latest research aims to discover alternatives to classical immunological and metabolic therapies. 

Heiko Lickert elaborates that therapies that sensitize cells to insulin protect the loss of beta-cells of the pancreas in diabetic patients. The discovery of insulin inhibitory receptors provides a molecular target for beta-cell protection. With the latest discovery, remission of diabetes will be possible. Moreover, regeneration therapy has no unwanted side-effects like that of intensive insulin therapy. 

Ansarullah was one of the first authors of the study. According to Ansarullah, an inceptor can treat the root cause of diabetes and dysfunction of beta cells. Moreover, it can prevent the loss of beta-cells. The study’s detailed findings are available in Nature and diabetes researchers at Helmholtz Zentrum Munchen. 

 

About the author

Adeena Tariq Lari

The author is a graduate of dental surgery from the Dow University Health Sciences, Karachi. She has an academic background in content writing as well as English literature, giving her an edge in the field. Adeena is always curious about physical and mental health. She is always passionate about research and delivering high-quality reliable content to users.

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