Toxin-Delivering Astrocytes May Cause Glaucoma Nerve Cells To Expire

Hopkins Medicine

Researchers at NYU Grossman School of Medicine conducted a rodent study recently and proved that after brain injury, a sort of glial cell that supports nerves may get neurotic. Consequently, it could get rid of nerve cells completely.

The study’s results demonstrated that this responsive behavior might be a driving variable behind neurodegenerative diseases. For instance, it could be glaucoma and other endless neurodegenerative infections of the eye.

However, this research is the first, proving that receptive astrocytes kill cells after some time in a procedure similar to what happens in glaucoma.

What is Glaucoma?

A high-ranked writer Shane Liddlelow, PhD was the head of the team’s paper published in Cell Reports. The paper discussed neuronal death and its possible causes, after retinal injury.

Liddlelow, an associate professor of psychology and neuroscience at NYU Langone Health added to the results. He explained that their findings conclude astrocytes as the main reason that causes neuronal death, especially considering glaucoma.

He continued that for the prevention of further decay, highlighting astrocytes after a medical issue (physical) may be the best step towards healthy neurons.

Glaucoma is an infection that harms the patient’s optic nerve. This infection normally happens when a certain type of liquid develops in the forward portion of the patient’s eye. That additional liquid expands the weight in the patient’s eye, harming the optic nerve.

Analysts conclude that scientists are aware of the process of degeneration of cells in this illness. But the cause of the degeneration of these cells is still unknown.

The Experiment

For their research, the specialists expanded IOP for about 14 days in a few genetically engineered mice and rats. They found that while the unmodified mice lost up to half of the neurons in the danger zone, those without poisonous astrocytes saw limited cell death.

The scientists analyzed the reactions of the neurons when they kept astrocytes away from the exposed poisons. As a result, a disturbing irritation in a portion of the animals to keep their astrocytes from getting responsive took place.

Strangely, neurons that remained kept on imparting electrical signs.

The group recorded that despite the alteration, RGCs (Reticularis Gigantocellularis) held a large extent of use in terms of the appropriate properties associated with the electrical reaction. Moreover, their idea of the electrophysical and biological focus of RGCs, consequently, saved from cell death was similar to another.

The other perception was that a healthy retina suggests that elimination of variables that activate receptive astrocytes, also prevents the several changes that take place regularly before the inevitable death of the cell.


The specialists came to the conclusion that these discoveries propose that receptive astrocytes are an amazing objective for restorative repair in intense wounds to the eye and that stopping the demise of RGCs may give a valuable stage to the recovery of the retina.

Additionally, the discoveries recommend that blocking astrocytes is a method for forestalling nerve harm in glaucoma patients. Liddelow alerts that there isn’t any confirmation yet as to whether the possible impacts are lasting, or what reactions may happen.

Moving on, the experimental group intends to research if the treatment really improves vision in creatures with glaucoma or not.

Specialists intend to consider astrocyte conduct in related infections as Parkinson’s, Amyotrophic lateral sclerosis, and Alzheimer’s.

The outcomes might be applicable in various neurodegenerative sicknesses. Researchers said that conclusions suggest that receptive astrocytes that are neurotoxic, might be the main cause of the reaction of the central nervous system and slowed injury.